diff --git a/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/CacheSupport.kt b/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/CacheSupport.kt
index 48cf21a951d..a7bd605846c 100644
--- a/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/CacheSupport.kt
+++ b/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/CacheSupport.kt
@@ -114,5 +114,10 @@ class CacheSupport(
                         "that is already cached in '${cache.path}'")
             }
         }
+
+        if ((librariesToCache.isNotEmpty() || cachedLibraries.hasDynamicCaches || cachedLibraries.hasStaticCaches)
+                && configuration.getBoolean(KonanConfigKeys.OPTIMIZATION)) {
+            configuration.reportCompilationError("Cache cannot be used in optimized compilation")
+        }
     }
 }
\ No newline at end of file