diff --git a/kotlin-native/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/Context.kt b/kotlin-native/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/Context.kt
index f60286cecd9..3df422002bd 100644
--- a/kotlin-native/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/Context.kt
+++ b/kotlin-native/backend.native/compiler/ir/backend.native/src/org/jetbrains/kotlin/backend/konan/Context.kt
@@ -1,6 +1,6 @@
 /*
- * Copyright 2010-2018 JetBrains s.r.o. Use of this source code is governed by the Apache 2.0 license
- * that can be found in the LICENSE file.
+ * Copyright 2010-2022 JetBrains s.r.o. and Kotlin Programming Language contributors.
+ * Use of this source code is governed by the Apache 2.0 license that can be found in the license/LICENSE.txt file.
  */
 
 package org.jetbrains.kotlin.backend.konan
@@ -41,6 +41,7 @@ import org.jetbrains.kotlin.konan.library.KonanLibraryLayout
 import org.jetbrains.kotlin.konan.target.Architecture
 import org.jetbrains.kotlin.konan.target.CompilerOutputKind
 import org.jetbrains.kotlin.konan.target.KonanTarget
+import org.jetbrains.kotlin.konan.target.needSmallBinary
 import org.jetbrains.kotlin.library.SerializedIrModule
 import org.jetbrains.kotlin.library.SerializedMetadata
 import org.jetbrains.kotlin.name.ClassId
@@ -318,10 +319,7 @@ internal class Context(config: KonanConfig) : KonanBackendContext(config) {
     fun shouldUseDebugInfoFromNativeLibs() = shouldContainAnyDebugInfo() && config.useDebugInfoInNativeLibs
 
     fun shouldOptimize() = config.optimizationsEnabled
-    fun shouldInlineSafepoints() = when {
-        config.target.family.isAppleFamily -> config.target.architecture != Architecture.ARM32 // disable for watchos_arm32 and similar
-        else -> true
-    }
+    fun shouldInlineSafepoints() = !config.target.needSmallBinary()
     fun ghaEnabled() = ::globalHierarchyAnalysisResult.isInitialized
     fun useLazyFileInitializers() = config.propertyLazyInitialization
 
diff --git a/kotlin-native/konan/konan.properties b/kotlin-native/konan/konan.properties
index 965ae99af18..7b311fdf2c0 100644
--- a/kotlin-native/konan/konan.properties
+++ b/kotlin-native/konan/konan.properties
@@ -131,7 +131,7 @@ linkerDynamicFlags.macos_x64 = -dylib
 
 osVersionMinFlagLd.macos_x64 = -macosx_version_min
 osVersionMin.macos_x64 = 10.13
-runtimeDefinitions.macos_x64 = KONAN_OSX=1 KONAN_MACOSX=1 KONAN_X64=1 KONAN_OBJC_INTEROP=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 dependencies.macos_x64 = \
     lldb-4-macos
 
@@ -170,7 +170,7 @@ linkerDynamicFlags.macos_arm64 = -dylib
 
 osVersionMinFlagLd.macos_arm64 = -macosx_version_min
 osVersionMin.macos_arm64 = 11.0
-runtimeDefinitions.macos_arm64 = KONAN_OSX=1 KONAN_MACOSX=1 KONAN_ARM64=1 KONAN_OBJC_INTEROP=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 dependencies.macos_arm64 = \
     lldb-4-macos
 
@@ -207,14 +207,8 @@ linkerKonanFlags.ios_arm32 = -lSystem -lc++ -lobjc -framework Foundation -framew
 linkerOptimizationFlags.ios_arm32 = -dead_strip
 osVersionMinFlagLd.ios_arm32 = -iphoneos_version_min
 osVersionMin.ios_arm32 = 9.0
-# Regarding KONAN_NO_64BIT_ATOMIC:
-# While not 100% correct here, using atomic ops on iOS armv7 requires 8 byte alignment,
-# and general ABI requires 4-byte alignment on 64-bit long fields as mentioned in
-# https://developer.apple.com/library/archive/documentation/Xcode/Conceptual/iPhoneOSABIReference/Articles/ARMv6FunctionCallingConventions.html#//apple_ref/doc/uid/TP40009021-SW1
-# See https://github.com/ktorio/ktor/issues/941 for the context.
-runtimeDefinitions.ios_arm32 = KONAN_OBJC_INTEROP=1 KONAN_IOS KONAN_ARM32=1 \
-  KONAN_REPORT_BACKTRACE_TO_IOS_CRASH_LOG=1 MACHSIZE=32 \
-  KONAN_NO_64BIT_ATOMIC=1 KONAN_NO_UNALIGNED_ACCESS=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
+   
 
 # Apple's 64-bit iOS.
 targetToolchain.macos_x64-ios_arm64 = target-toolchain-xcode_13_1
@@ -241,8 +235,7 @@ linkerKonanFlags.ios_arm64 = -lSystem -lc++ -lobjc -framework Foundation -framew
 linkerOptimizationFlags.ios_arm64 = -dead_strip
 osVersionMinFlagLd.ios_arm64 = -iphoneos_version_min
 osVersionMin.ios_arm64 = 9.0
-runtimeDefinitions.ios_arm64 = KONAN_OBJC_INTEROP=1 KONAN_IOS=1 KONAN_ARM64=1 \
-  KONAN_REPORT_BACKTRACE_TO_IOS_CRASH_LOG=1 MACHSIZE=64 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
 additionalCacheFlags.ios_arm64 = -Xembed-bitcode-marker
 
 #  Apple's iOS simulator.
@@ -267,7 +260,7 @@ stripFlags.ios_x64 = -S
 linkerDynamicFlags.ios_x64 = -dylib
 osVersionMinFlagLd.ios_x64 = -ios_simulator_version_min
 osVersionMin.ios_x64 = 9.0
-runtimeDefinitions.ios_x64 = KONAN_OBJC_INTEROP=1 KONAN_IOS=1 KONAN_X64=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
 
 # iOS simulator on Apple Silicon
 
@@ -292,7 +285,7 @@ stripFlags.ios_simulator_arm64 = -S
 linkerDynamicFlags.ios_simulator_arm64 = -dylib
 osVersionMinFlagLd.ios_simulator_arm64 = -ios_simulator_version_min
 osVersionMin.ios_simulator_arm64 = 9.0
-runtimeDefinitions.ios_simulator_arm64 = KONAN_OBJC_INTEROP=1 KONAN_IOS=1 KONAN_ARM64=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
 
 #  Apple's tvOS simulator.
 targetToolchain.macos_x64-tvos_x64 = target-toolchain-xcode_13_1
@@ -316,7 +309,7 @@ stripFlags.tvos_x64 = -S
 linkerDynamicFlags.tvos_x64 = -dylib
 osVersionMinFlagLd.tvos_x64 = -tvos_simulator_version_min
 osVersionMin.tvos_x64 = 9.0
-runtimeDefinitions.tvos_x64 = KONAN_OBJC_INTEROP=1 KONAN_TVOS=1 KONAN_X64=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
 
 #  Apple's tvOS simulator.
 targetToolchain.macos_x64-tvos_simulator_arm64 = target-toolchain-xcode_13_1
@@ -340,7 +333,7 @@ stripFlags.tvos_simulator_arm64 = -S
 linkerDynamicFlags.tvos_simulator_arm64 = -dylib
 osVersionMinFlagLd.tvos_simulator_arm64 = -tvos_simulator_version_min
 osVersionMin.tvos_simulator_arm64 = 9.0
-runtimeDefinitions.tvos_simulator_arm64 = KONAN_OBJC_INTEROP=1 KONAN_TVOS=1 KONAN_ARM64=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
 
 # Apple's 64-bit tvOS.
 targetToolchain.macos_x64-tvos_arm64 = target-toolchain-xcode_13_1
@@ -364,8 +357,7 @@ linkerKonanFlags.tvos_arm64 = -lSystem -lc++ -lobjc -framework Foundation -frame
 linkerOptimizationFlags.tvos_arm64 = -dead_strip
 osVersionMinFlagLd.tvos_arm64 = -tvos_version_min
 osVersionMin.tvos_arm64 = 9.0
-runtimeDefinitions.tvos_arm64 = KONAN_OBJC_INTEROP=1 KONAN_TVOS=1 KONAN_ARM64=1 \
-  KONAN_REPORT_BACKTRACE_TO_IOS_CRASH_LOG=1 MACHSIZE=64 KONAN_HAS_FOUNDATION_FRAMEWORK=1 KONAN_HAS_UIKIT_FRAMEWORK=1
+
 
 # watchOS armv7k
 targetToolchain.macos_x64-watchos_arm32 = target-toolchain-xcode_13_1
@@ -390,10 +382,7 @@ stripFlags.watchos_arm32 = -S
 linkerDynamicFlags.watchos_arm32 = -dylib
 osVersionMinFlagLd.watchos_arm32 = -watchos_version_min
 osVersionMin.watchos_arm32 = 5.0
-# Regarding KONAN_NO_64BIT_ATOMIC=1: see explanation for ios_arm32 above.
-runtimeDefinitions.watchos_arm32 = KONAN_OBJC_INTEROP=1 KONAN_WATCHOS KONAN_ARM32=1 \
-  KONAN_REPORT_BACKTRACE_TO_IOS_CRASH_LOG=1 \
-  MACHSIZE=32 KONAN_NO_64BIT_ATOMIC=1 KONAN_NO_UNALIGNED_ACCESS=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 
 # watchOS arm64_32
 targetToolchain.macos_x64-watchos_arm64 = target-toolchain-xcode_13_1
@@ -415,10 +404,7 @@ stripFlags.watchos_arm64 = -S
 linkerDynamicFlags.watchos_arm64 = -dylib
 osVersionMinFlagLd.watchos_arm64 = -watchos_version_min
 osVersionMin.watchos_arm64 = 5.0
-# Regarding KONAN_NO_64BIT_ATOMIC=1: see explanation for ios_arm32 above.
-runtimeDefinitions.watchos_arm64 = KONAN_OBJC_INTEROP=1 KONAN_WATCHOS KONAN_ARM32=1 \
-  KONAN_REPORT_BACKTRACE_TO_IOS_CRASH_LOG=1 \
-  MACHSIZE=32 KONAN_NO_64BIT_ATOMIC=1 KONAN_NO_UNALIGNED_ACCESS=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 
 #  Apple's watchOS i386 simulator.
 targetToolchain.macos_x64-watchos_x86 = target-toolchain-xcode_13_1
@@ -443,7 +429,7 @@ stripFlags.watchos_x86 = -S
 linkerDynamicFlags.watchos_x86 = -dylib
 osVersionMinFlagLd.watchos_x86 = -watchos_simulator_version_min
 osVersionMin.watchos_x86 = 5.0
-runtimeDefinitions.watchos_x86 = KONAN_OBJC_INTEROP=1 KONAN_WATCHOS=1 KONAN_NO_64BIT_ATOMIC=1 KONAN_X86=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 
 # watchOS x86_64 simulator.
 targetToolchain.macos_x64-watchos_x64 = target-toolchain-xcode_13_1
@@ -467,7 +453,7 @@ stripFlags.watchos_x64 = -S
 linkerDynamicFlags.watchos_x64 = -dylib
 osVersionMinFlagLd.watchos_x64 = -watchos_simulator_version_min
 osVersionMin.watchos_x64 = 7.0
-runtimeDefinitions.watchos_x64 = KONAN_OBJC_INTEROP=1 KONAN_WATCHOS=1 KONAN_X64=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 
 # watchOS Apple Silicon simulator.
 targetToolchain.macos_x64-watchos_simulator_arm64 = target-toolchain-xcode_13_1
@@ -491,7 +477,7 @@ stripFlags.watchos_simulator_arm64 = -S
 linkerDynamicFlags.watchos_simulator_arm64 = -dylib
 osVersionMinFlagLd.watchos_simulator_arm64 = -watchos_simulator_version_min
 osVersionMin.watchos_simulator_arm64 = 7.0
-runtimeDefinitions.watchos_simulator_arm64 = KONAN_OBJC_INTEROP=1 KONAN_WATCHOS=1 KONAN_ARM64=1 KONAN_HAS_FOUNDATION_FRAMEWORK=1
+
 
 
 # Linux x86-64.
@@ -551,8 +537,7 @@ dynamicLinker.linux_x64 = /lib64/ld-linux-x86-64.so.2
 abiSpecificLibraries.linux_x64 = lib usr/lib ../lib64 lib64 usr/lib64
 # targetSysRoot relative
 crtFilesLocation.linux_x64 = usr/lib
-runtimeDefinitions.linux_x64 = USE_GCC_UNWIND=1 KONAN_LINUX=1 KONAN_X64=1 \
-  USE_ELF_SYMBOLS=1 ELFSIZE=64
+
 
 # Raspberry Pi
 gccToolchain.linux_arm32_hfp = $toolchainDependency.linux_arm32_hfp
@@ -611,9 +596,7 @@ dynamicLinker.linux_arm32_hfp = /lib/ld-linux-armhf.so.3
 abiSpecificLibraries.linux_arm32_hfp = lib usr/lib
 # targetSysRoot relative
 crtFilesLocation.linux_arm32_hfp = usr/lib
-runtimeDefinitions.linux_arm32_hfp = USE_GCC_UNWIND=1 KONAN_LINUX=1 \
-  KONAN_ARM32=1 USE_ELF_SYMBOLS=1 ELFSIZE=32 KONAN_NO_UNALIGNED_ACCESS=1 \
-  KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
+
 
 # Linux arm64
 gccToolchain.linux_arm64 = $toolchainDependency.linux_arm64
@@ -668,8 +651,7 @@ dynamicLinker.linux_arm64 = /lib/ld-linux-aarch64.so.1
 abiSpecificLibraries.linux_arm64 = lib usr/lib
 # targetSysRoot relative
 crtFilesLocation.linux_arm64 = usr/lib
-runtimeDefinitions.linux_arm64 = USE_GCC_UNWIND=1 KONAN_LINUX=1 KONAN_ARM64=1 \
-  USE_ELF_SYMBOLS=1 ELFSIZE=64
+
 
 # MIPS
 gccToolchain.linux_mips32 = $toolchainDependency.linux_mips32
@@ -721,10 +703,7 @@ dynamicLinker.linux_mips32 = /lib/ld.so.1
 abiSpecificLibraries.linux_mips32 = lib usr/lib
 # targetSysRoot relative
 crtFilesLocation.linux_mips32 = usr/lib
-# TODO: reconsider KONAN_NO_64BIT_ATOMIC, once target MIPS can do proper 64-bit load/store/CAS.
-runtimeDefinitions.linux_mips32 = USE_GCC_UNWIND=1 KONAN_LINUX=1 KONAN_MIPS32=1 \
-  USE_ELF_SYMBOLS=1 ELFSIZE=32 KONAN_NO_64BIT_ATOMIC=1 KONAN_NO_UNALIGNED_ACCESS=1 \
-  KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
+
 
 # MIPSel
 gccToolchain.linux_mipsel32 = $toolchainDependency.linux_mipsel32
@@ -773,10 +752,7 @@ dynamicLinker.linux_mipsel32 = /lib/ld.so.1
 abiSpecificLibraries.linux_mipsel32 = lib usr/lib
 # targetSysRoot relative
 crtFilesLocation.linux_mipsel32 = usr/lib
-# TODO: reconsider KONAN_NO_64BIT_ATOMIC, once target MIPS can do proper 64-bit load/store/CAS.
-runtimeDefinitions.linux_mipsel32 = USE_GCC_UNWIND=1 KONAN_LINUX=1 \
-  KONAN_MIPSEL32=1 USE_ELF_SYMBOLS=1 ELFSIZE=32 KONAN_NO_64BIT_ATOMIC=1 KONAN_NO_UNALIGNED_ACCESS=1 \
-  KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
+
 
 # Android ARM32, based on NDK for android-21.
 targetToolchain.macos_x64-android_arm32 = target-toolchain-2-osx-android_ndk
@@ -805,9 +781,7 @@ linkerNoDebugFlags.android_arm32 = -Wl,-S
 clangNooptFlags.android_arm32 = -O1
 targetSysRoot.android_arm32 = target-sysroot-1-android_ndk
 linkerKonanFlags.android_arm32 = -lm -lc++_static -lc++abi -landroid -llog -latomic
-runtimeDefinitions.android_arm32 = __ANDROID__ USE_GCC_UNWIND=1 USE_ELF_SYMBOLS=1 ELFSIZE=32 \
-  KONAN_ANDROID=1 KONAN_ARM32=1 KONAN_NO_UNALIGNED_ACCESS=1 KONAN_NO_64BIT_ATOMIC=1 \
-  KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
+
 
 # Android ARM64, based on NDK.
 targetToolchain.macos_x64-android_arm64 = target-toolchain-2-osx-android_ndk
@@ -835,8 +809,7 @@ clangNooptFlags.android_arm64 = -O1
 targetSysRoot.android_arm64 = target-sysroot-1-android_ndk
 linkerKonanFlags.android_arm64 = -lm -lc++_static -lc++abi -landroid -llog -latomic
 linkerNoDebugFlags.android_arm64 = -Wl,-S
-runtimeDefinitions.android_arm64 = __ANDROID__ USE_GCC_UNWIND=1 USE_ELF_SYMBOLS=1 \
-  ELFSIZE=64 KONAN_ANDROID=1 KONAN_ARM64=1
+
 
 # Android X86, based on NDK.
 targetToolchain.macos_x64-android_x86 = target-toolchain-2-osx-android_ndk
@@ -865,8 +838,7 @@ clangNooptFlags.android_x86 = -O1
 targetSysRoot.android_x86 = target-sysroot-1-android_ndk
 linkerKonanFlags.android_x86 = -lm -lc++_static -lc++abi -landroid -llog -latomic
 linkerNoDebugFlags.android_x86 = -Wl,-S
-runtimeDefinitions.android_x86 = __ANDROID__ USE_GCC_UNWIND=1 USE_ELF_SYMBOLS=1 \
-  ELFSIZE=32 KONAN_ANDROID=1 KONAN_X86=1 KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
+
 
 # Android X64, based on NDK.
 targetToolchain.macos_x64-android_x64 = target-toolchain-2-osx-android_ndk
@@ -894,8 +866,7 @@ clangNooptFlags.android_x64 = -O1
 targetSysRoot.android_x64 = target-sysroot-1-android_ndk
 linkerKonanFlags.android_x64 = -lm -lc++_static -lc++abi -landroid -llog -latomic
 linkerNoDebugFlags.android_x64 = -Wl,-S
-runtimeDefinitions.android_x64 = __ANDROID__ USE_GCC_UNWIND=1 USE_ELF_SYMBOLS=1 \
-  ELFSIZE=64 KONAN_ANDROID=1 KONAN_X64=1
+
 
 # Windows x86-64, based on mingw-w64.
 llvmHome.mingw_x64 = $llvm.mingw_x64.dev
@@ -945,8 +916,7 @@ linkerKonanFlags.mingw_x64 =-static-libgcc -static-libstdc++ \
   -Wl,-Bstatic,--whole-archive -lwinpthread -Wl,--no-whole-archive,-Bdynamic
 linkerOptimizationFlags.mingw_x64 = -Wl,--gc-sections
 mimallocLinkerDependencies.mingw_x64 = -lbcrypt
-runtimeDefinitions.mingw_x64 = USE_GCC_UNWIND=1 USE_PE_COFF_SYMBOLS=1 KONAN_WINDOWS=1 \
-  UNICODE KONAN_X64=1 KONAN_NO_MEMMEM=1
+
 
 # Windows i686, based on mingw-w64.
 targetToolchain.mingw_x64-mingw_x86 = $toolchainDependency.mingw_x86
@@ -986,8 +956,7 @@ linkerKonanFlags.mingw_x86 = -static-libgcc -static-libstdc++ \
   -Wl,-Bstatic,--whole-archive -lwinpthread -Wl,--no-whole-archive,-Bdynamic
 mimallocLinkerDependencies.mingw_x86 = -lbcrypt
 linkerOptimizationFlags.mingw_x86 = -Wl,--gc-sections
-runtimeDefinitions.mingw_x86 = USE_GCC_UNWIND=1 USE_PE_COFF_SYMBOLS=1 KONAN_WINDOWS=1 \
-  UNICODE KONAN_X86=1 KONAN_NO_MEMMEM=1 KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
+
 
 # WebAssembly 32-bit.
 targetToolchain.macos_x64-wasm32 = target-toolchain-3-macos-wasm
@@ -1019,10 +988,6 @@ clangOptFlags.wasm32 = -O3
 clangDebugFlags.wasm32 = -O0
 # TODO: make explicit list of external symbols
 lld.wasm32 = --allow-undefined --no-entry --global-base=0 --export-dynamic
-runtimeDefinitions.wasm32 = KONAN_WASM=1 KONAN_NO_FFI=1 KONAN_NO_THREADS=1 \
-  KONAN_NO_EXCEPTIONS=1 KONAN_INTERNAL_DLMALLOC=1 KONAN_INTERNAL_SNPRINTF=1 \
-  KONAN_INTERNAL_NOW=1 KONAN_NO_MEMMEM KONAN_NO_CTORS_SECTION=1 KONAN_NO_BACKTRACE=1 \
-  KONAN_NO_EXTERNAL_CALLS_CHECKER=1 KONAN_FORBID_BUILTIN_MUL_OVERFLOW=1
 
 # The version of Kotlin/Native compiler
 compilerVersion=@compilerVersion@
diff --git a/kotlin-native/konan/platforms/zephyr/stm32f4_disco b/kotlin-native/konan/platforms/zephyr/stm32f4_disco
index 723d4eac6af..b00158ef8e1 100644
--- a/kotlin-native/konan/platforms/zephyr/stm32f4_disco
+++ b/kotlin-native/konan/platforms/zephyr/stm32f4_disco
@@ -24,10 +24,6 @@ boardSpecificClangFlags.zephyr_stm32f4_disco = -mthumb
 targetCpu.zephyr_stm32f4_disco = cortex-m4
 targetAbi.zephyr_stm32f4_disco = aapcs
 clangFlags = -Os
-runtimeDefinitions.zephyr_stm32f4_disco = KONAN_ZEPHYR=1 KONAN_NO_FFI=1 \
-  KONAN_NO_THREADS=1 KONAN_NO_EXCEPTIONS=1 KONAN_NO_MATH=1 \
-  KONAN_INTERNAL_SNPRINTF=1 KONAN_INTERNAL_NOW=1 KONAN_NO_MEMMEM=1 \
-  KONAN_NO_CTORS_SECTION=1 KONAN_NO_UNALIGNED_ACCESS=1 KONAN_NO_BACKTRACE=1
 
 targetToolchain.linux_x64-zephyr_stm32f4_disco = gcc-arm-none-eabi-7-2017-q4-major-linux/arm-none-eabi
 dependencies.linux_x64-zephyr_stm32f4_disco = \
diff --git a/kotlin-native/runtime/src/main/cpp/Common.h b/kotlin-native/runtime/src/main/cpp/Common.h
index ab9a544a722..30bdedbca21 100644
--- a/kotlin-native/runtime/src/main/cpp/Common.h
+++ b/kotlin-native/runtime/src/main/cpp/Common.h
@@ -25,7 +25,7 @@
 #define RUNTIME_WEAK __attribute__((weak))
 #define RUNTIME_NODEBUG __attribute__((nodebug))
 
-#if KONAN_ARM32 && (KONAN_IOS || KONAN_WATCHOS)
+#if KONAN_NEAD_SMALL_BINARY
   // On the one hand, ALWAYS_INLINE forces many performance-critical function to be, well,
   // inlined. Which is good for performance, of course.
   // On the other hand, 32-bit Mach-O object files can't be really big.
@@ -52,9 +52,5 @@
 #define KONAN_TYPE_INFO_HAS_WRITABLE_PART 1
 #endif
 
-// should be consistent with hasAddressDependencyInMemoryModel function
-#if defined(KONAN_X64) || defined(KONAN_X86) || defined(KONAN_ARM32) || defined(KONAN_ARM64)
-#define KONAN_TARGET_HAS_ADDRESS_DEPENDENCY 1
-#endif
 
 #endif // RUNTIME_COMMON_H
diff --git a/kotlin-native/runtime/src/main/cpp/Memory.h b/kotlin-native/runtime/src/main/cpp/Memory.h
index 38404031a6d..898e211118b 100644
--- a/kotlin-native/runtime/src/main/cpp/Memory.h
+++ b/kotlin-native/runtime/src/main/cpp/Memory.h
@@ -26,7 +26,7 @@
 #include "PointerBits.h"
 #include "Utils.hpp"
 
-#if KONAN_ARM32 && (KONAN_IOS || KONAN_WATCHOS)
+#if KONAN_NEAD_SMALL_BINARY
   // Currently, codegen places a lot of unnecessary calls to MM functions.
   // By forcing NO_INLINE on these functions we keep binaries from growing too big.
   #define CODEGEN_INLINE_POLICY NO_INLINE
diff --git a/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/ClangArgs.kt b/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/ClangArgs.kt
index 6e8185196b5..30fe5dfc782 100644
--- a/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/ClangArgs.kt
+++ b/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/ClangArgs.kt
@@ -1,17 +1,6 @@
 /*
- * Copyright 2010-2017 JetBrains s.r.o.
- *
- * Licensed under the Apache License, Version 2.0 (the "License");
- * you may not use this file except in compliance with the License.
- * You may obtain a copy of the License at
- *
- * http://www.apache.org/licenses/LICENSE-2.0
- *
- * Unless required by applicable law or agreed -> in writing, software
- * distributed under the License is distributed on an "AS IS" BASIS,
- * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
- * See the License for the specific language governing permissions and
- * limitations under the License.
+ * Copyright 2010-2022 JetBrains s.r.o. and Kotlin Programming Language contributors.
+ * Use of this source code is governed by the Apache 2.0 license that can be found in the license/LICENSE.txt file.
  */
 
 package org.jetbrains.kotlin.konan.target
@@ -45,8 +34,41 @@ sealed class ClangArgs(
     // TODO: Should be dropped in favor of real MSVC target.
     private val argsForWindowsJni = forJni && target == KonanTarget.MINGW_X64
 
-    private val clangArgsSpecificForKonanSources
-        get() = configurables.runtimeDefinitions.map { "-D$it" }
+    private val clangArgsSpecificForKonanSources : List<String>
+        get() {
+            val konanOptions = listOfNotNull(
+                    target.architecture.name.takeIf { target != KonanTarget.WATCHOS_ARM64 },
+                    "ARM32".takeIf { target == KonanTarget.WATCHOS_ARM64 },
+                    target.family.name.takeIf { target.family != Family.MINGW },
+                    "WINDOWS".takeIf { target.family == Family.MINGW },
+                    "MACOSX".takeIf { target.family == Family.OSX },
+
+                    "NO_THREADS".takeUnless { target.supportsThreads() },
+                    "NO_EXCEPTIONS".takeUnless { target.supportsExceptions() },
+                    "NO_MEMMEM".takeUnless { target.suportsMemMem() },
+                    "NO_64BIT_ATOMIC".takeUnless { target.supports64BitAtomics() },
+                    "NO_UNALIGNED_ACCESS".takeUnless { target.supportsUnalignedAccess() },
+                    "FORBID_BUILTIN_MUL_OVERFLOW".takeUnless { target.supports64BitMulOverflow() },
+
+                    "OBJC_INTEROP".takeIf { target.supportsObjcInterop() },
+                    "HAS_FOUNDATION_FRAMEWORK".takeIf { target.hasFoundationFramework() },
+                    "HAS_UIKIT_FRAMEWORK".takeIf { target.hasUIKitFramework() },
+                    "REPORT_BACKTRACE_TO_IOS_CRASH_LOG".takeIf { target.supportsIosCrashLog() },
+                    "NEAD_SMALL_BINARY".takeIf { target.needSmallBinary() },
+                    "TARGET_HAS_ADDRESS_DEPENDENCY".takeIf { target.hasAddressDependencyInMemoryModel() },
+            ).map { "KONAN_$it=1" }
+            val otherOptions = listOfNotNull(
+                    "USE_ELF_SYMBOLS=1".takeIf { target.binaryFormat() == BinaryFormat.ELF },
+                    "ELFSIZE=${target.pointerBits()}".takeIf { target.binaryFormat() == BinaryFormat.ELF },
+                    "MACHSIZE=${target.pointerBits()}".takeIf { target.binaryFormat() == BinaryFormat.MACH_O },
+                    "__ANDROID__".takeIf { target.family == Family.ANDROID },
+                    "USE_PE_COFF_SYMBOLS=1".takeIf { target.binaryFormat() == BinaryFormat.PE_COFF },
+                    "UNICODE".takeIf { target.family == Family.MINGW },
+                    "USE_GCC_UNWIND=1".takeIf { target.supportsGccUnwind() }
+            )
+            val customOptions = target.customArgsForKonanSources()
+            return (konanOptions + otherOptions + customOptions).map { "-D$it" }
+        }
 
     private val binDir = when (HostManager.host) {
         KonanTarget.LINUX_X64 -> "$absoluteTargetToolchain/bin"
diff --git a/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/KonanTargetExtenstions.kt b/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/KonanTargetExtenstions.kt
index eb009688e49..a9011a50fd9 100644
--- a/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/KonanTargetExtenstions.kt
+++ b/kotlin-native/shared/src/main/kotlin/org/jetbrains/kotlin/konan/target/KonanTargetExtenstions.kt
@@ -5,7 +5,33 @@
 
 package org.jetbrains.kotlin.konan.target
 
-// TODO: This all needs to go to konan.properties
+enum class BinaryFormat {
+    ELF,
+    PE_COFF,
+    MACH_O
+}
+
+fun KonanTarget.binaryFormat() = when (family) {
+    Family.WATCHOS -> BinaryFormat.MACH_O
+    Family.IOS -> BinaryFormat.MACH_O
+    Family.TVOS -> BinaryFormat.MACH_O
+    Family.OSX -> BinaryFormat.MACH_O
+    Family.ANDROID -> BinaryFormat.ELF
+    Family.LINUX -> BinaryFormat.ELF
+    Family.MINGW -> BinaryFormat.PE_COFF
+    Family.WASM, Family.ZEPHYR -> null
+}
+
+fun KonanTarget.pointerBits() = when (architecture) {
+    Architecture.X64 -> 64
+    Architecture.X86 -> 32
+    Architecture.ARM64 -> if (this == KonanTarget.WATCHOS_ARM64) 32 else 64
+    Architecture.ARM32 -> 32
+    Architecture.MIPS32 -> 32
+    Architecture.MIPSEL32 -> 32
+    Architecture.WASM32 -> 32
+}
+
 
 fun KonanTarget.supportsCodeCoverage(): Boolean =
         // TODO: Disabled for now, because we don't support
@@ -46,13 +72,71 @@ fun KonanTarget.supportsCoreSymbolication(): Boolean =
                 KonanTarget.WATCHOS_X86, KonanTarget.WATCHOS_X64, KonanTarget.WATCHOS_SIMULATOR_ARM64
         )
 
+fun KonanTarget.supportsGccUnwind(): Boolean = family == Family.ANDROID || family == Family.LINUX || family == Family.MINGW
 
-fun KonanTarget.supportsThreads(): Boolean =
-     when(this) {
-        is KonanTarget.WASM32 -> false
-        is KonanTarget.ZEPHYR -> false
-        else -> true
-     }
+
+fun KonanTarget.supportsThreads(): Boolean = when(this) {
+    is KonanTarget.WASM32 -> false
+    is KonanTarget.ZEPHYR -> false
+    else -> true
+}
+
+fun KonanTarget.supportsExceptions(): Boolean = when(this) {
+    is KonanTarget.WASM32 -> false
+    is KonanTarget.ZEPHYR -> false
+    else -> true
+}
+
+fun KonanTarget.suportsMemMem(): Boolean = when (this) {
+    is KonanTarget.WASM32 -> false
+    is KonanTarget.MINGW_X86 -> false
+    is KonanTarget.MINGW_X64 -> false
+    is KonanTarget.ZEPHYR -> false
+    else -> true
+}
+
+fun KonanTarget.supportsObjcInterop(): Boolean = family.isAppleFamily
+fun KonanTarget.hasFoundationFramework(): Boolean = family.isAppleFamily
+fun KonanTarget.hasUIKitFramework(): Boolean = family == Family.IOS || family == Family.TVOS
+fun KonanTarget.supports64BitMulOverflow(): Boolean = when (this) {
+    is KonanTarget.MINGW_X86 -> false
+    is KonanTarget.LINUX_ARM32_HFP -> false
+    is KonanTarget.LINUX_MIPS32 -> false
+    is KonanTarget.LINUX_MIPSEL32 -> false
+    is KonanTarget.WASM32 -> false
+    is KonanTarget.ZEPHYR -> false
+    is KonanTarget.ANDROID_ARM32 -> false
+    is KonanTarget.ANDROID_X86 -> false
+    else -> true
+}
+
+fun KonanTarget.supportsIosCrashLog(): Boolean = when (this) {
+    KonanTarget.IOS_ARM32 -> true
+    KonanTarget.IOS_ARM64 -> true
+    KonanTarget.WATCHOS_ARM32 -> true
+    KonanTarget.WATCHOS_ARM64 -> true
+    KonanTarget.TVOS_ARM64 -> true
+    else -> false
+}
+
+/*
+ * While not 100% correct here, using atomic ops on iOS armv7 requires 8 byte alignment,
+ * and general ABI requires 4-byte alignment on 64-bit long fields as mentioned in
+ * https://developer.apple.com/library/archive/documentation/Xcode/Conceptual/iPhoneOSABIReference/Articles/ARMv6FunctionCallingConventions.html#//apple_ref/doc/uid/TP40009021-SW1
+ * See https://github.com/ktorio/ktor/issues/941 for the context.
+ * TODO: reconsider once target MIPS can do proper 64-bit load/store/CAS.
+ */
+fun KonanTarget.supports64BitAtomics(): Boolean = when (architecture) {
+    Architecture.ARM32, Architecture.WASM32, Architecture.MIPS32, Architecture.MIPSEL32 -> false
+    Architecture.X86, Architecture.ARM64, Architecture.X64 -> true
+} && this != KonanTarget.WATCHOS_ARM64 && this != KonanTarget.WATCHOS_X86
+
+fun KonanTarget.supportsUnalignedAccess(): Boolean = when (architecture) {
+    Architecture.ARM32, Architecture.WASM32, Architecture.MIPS32, Architecture.MIPSEL32 -> false
+    Architecture.X86, Architecture.ARM64, Architecture.X64 -> true
+} && this != KonanTarget.WATCHOS_ARM64
+
+fun KonanTarget.needSmallBinary() = (architecture == Architecture.ARM32 && family.isAppleFamily) || this == KonanTarget.WATCHOS_ARM64
 
 fun KonanTarget.supportedSanitizers(): List<SanitizerKind> =
     when(this) {
@@ -65,9 +149,32 @@ fun KonanTarget.supportedSanitizers(): List<SanitizerKind> =
         else -> listOf()
     }
 
-// should be consistent with KONAN_TARGET_HAS_ADDRESS_DEPENDENCY macro
 fun KonanTarget.hasAddressDependencyInMemoryModel(): Boolean =
      when (this.architecture) {
          Architecture.X86, Architecture.X64, Architecture.ARM32, Architecture.ARM64 -> true
          Architecture.MIPS32, Architecture.MIPSEL32, Architecture.WASM32 -> false
      }
+
+
+// TODO: this is bad function. It should be replaced by capabilities functions like above
+// but two affected targets are too strange, so we postpone it
+fun KonanTarget.customArgsForKonanSources() = when (this) {
+    KonanTarget.WASM32 -> listOf(
+            "KONAN_NO_FFI=1",
+            "KONAN_INTERNAL_DLMALLOC=1",
+            "KONAN_INTERNAL_SNPRINTF=1",
+            "KONAN_INTERNAL_NOW=1",
+            "KONAN_NO_CTORS_SECTION=1",
+            "KONAN_NO_BACKTRACE=1",
+            "KONAN_NO_EXTERNAL_CALLS_CHECKER=1",
+    )
+    is KonanTarget.ZEPHYR -> listOf(
+            "KONAN_NO_FFI=1",
+            "KONAN_NO_MATH=1",
+            "KONAN_INTERNAL_SNPRINTF=1",
+            "KONAN_INTERNAL_NOW=1",
+            "KONAN_NO_CTORS_SECTION=1",
+            "KONAN_NO_BACKTRACE=1"
+    )
+    else -> emptyList()
+}
\ No newline at end of file