diff --git a/compiler/ir/backend.jvm/src/org/jetbrains/kotlin/backend/jvm/lower/SingleAbstractMethodLowering.kt b/compiler/ir/backend.jvm/src/org/jetbrains/kotlin/backend/jvm/lower/SingleAbstractMethodLowering.kt
index 5966c0f3ca7..60b053e97d5 100644
--- a/compiler/ir/backend.jvm/src/org/jetbrains/kotlin/backend/jvm/lower/SingleAbstractMethodLowering.kt
+++ b/compiler/ir/backend.jvm/src/org/jetbrains/kotlin/backend/jvm/lower/SingleAbstractMethodLowering.kt
@@ -28,6 +28,7 @@ import org.jetbrains.kotlin.ir.declarations.IrDeclarationOrigin
 import org.jetbrains.kotlin.ir.declarations.IrFile
 import org.jetbrains.kotlin.ir.declarations.IrFunction
 import org.jetbrains.kotlin.ir.expressions.IrExpression
+import org.jetbrains.kotlin.ir.expressions.IrGetValue
 import org.jetbrains.kotlin.ir.expressions.IrTypeOperator
 import org.jetbrains.kotlin.ir.expressions.IrTypeOperatorCall
 import org.jetbrains.kotlin.ir.expressions.impl.IrInstanceInitializerCallImpl
@@ -120,6 +121,15 @@ class SingleAbstractMethodLowering(val context: CommonBackendContext) : FileLowe
                     }
                     +irIfNull(superType, irGet(invokableVariable), irNull(), instance)
                 }
+            } else if (invokable !is IrGetValue) {
+                // Hack for the JVM inliner: since the SAM wrappers might be regenerated, avoid putting complex logic
+                // between the creation of the wrapper and the call of its `<init>`. `MethodInliner` tends to break
+                // otherwise, e.g. if the argument constructs an anonymous object, resulting in new-new-<init>-<init>.
+                // (See KT-21781 for a similar problem with anonymous object constructor arguments.)
+                irBlock(invokable, null, superType) {
+                    val invokableVariable = irTemporary(invokable)
+                    +irCall(implementation.constructors.single()).apply { putValueArgument(0, irGet(invokableVariable)) }
+                }
             } else {
                 irCall(implementation.constructors.single()).apply { putValueArgument(0, invokable) }
             }
diff --git a/compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt b/compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt
new file mode 100644
index 00000000000..fcb940529d3
--- /dev/null
+++ b/compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt
@@ -0,0 +1,16 @@
+// IGNORE_BACKEND: JVM_IR
+// FILE: 1.kt
+package test
+
+inline fun f(crossinline g: () -> Unit) = Runnable(object : () -> Unit {
+    override fun invoke() = g()
+})
+
+// FILE: 2.kt
+import test.*
+
+fun box(): String {
+    var result = "FAIL"
+    f { result = "OK" }.run()
+    return result
+}
diff --git a/compiler/tests/org/jetbrains/kotlin/codegen/BlackBoxInlineCodegenTestGenerated.java b/compiler/tests/org/jetbrains/kotlin/codegen/BlackBoxInlineCodegenTestGenerated.java
index da07ed70afc..eb4d411046c 100644
--- a/compiler/tests/org/jetbrains/kotlin/codegen/BlackBoxInlineCodegenTestGenerated.java
+++ b/compiler/tests/org/jetbrains/kotlin/codegen/BlackBoxInlineCodegenTestGenerated.java
@@ -432,6 +432,11 @@ public class BlackBoxInlineCodegenTestGenerated extends AbstractBlackBoxInlineCo
                 KotlinTestUtils.assertAllTestsPresentByMetadata(this.getClass(), new File("compiler/testData/codegen/boxInline/anonymousObject/sam"), Pattern.compile("^(.+)\\.kt$"), TargetBackend.JVM, true);
             }
 
+            @TestMetadata("anonymousObjectToSam.kt")
+            public void testAnonymousObjectToSam() throws Exception {
+                runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt");
+            }
+
             @TestMetadata("kt17091.kt")
             public void testKt17091() throws Exception {
                 runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/kt17091.kt");
diff --git a/compiler/tests/org/jetbrains/kotlin/codegen/CompileKotlinAgainstInlineKotlinTestGenerated.java b/compiler/tests/org/jetbrains/kotlin/codegen/CompileKotlinAgainstInlineKotlinTestGenerated.java
index a4d769d538d..ebcb5cbcb80 100644
--- a/compiler/tests/org/jetbrains/kotlin/codegen/CompileKotlinAgainstInlineKotlinTestGenerated.java
+++ b/compiler/tests/org/jetbrains/kotlin/codegen/CompileKotlinAgainstInlineKotlinTestGenerated.java
@@ -432,6 +432,11 @@ public class CompileKotlinAgainstInlineKotlinTestGenerated extends AbstractCompi
                 KotlinTestUtils.assertAllTestsPresentByMetadata(this.getClass(), new File("compiler/testData/codegen/boxInline/anonymousObject/sam"), Pattern.compile("^(.+)\\.kt$"), TargetBackend.JVM, true);
             }
 
+            @TestMetadata("anonymousObjectToSam.kt")
+            public void testAnonymousObjectToSam() throws Exception {
+                runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt");
+            }
+
             @TestMetadata("kt17091.kt")
             public void testKt17091() throws Exception {
                 runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/kt17091.kt");
diff --git a/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrBlackBoxInlineCodegenTestGenerated.java b/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrBlackBoxInlineCodegenTestGenerated.java
index 8bb52efc1ba..9d6106b28aa 100644
--- a/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrBlackBoxInlineCodegenTestGenerated.java
+++ b/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrBlackBoxInlineCodegenTestGenerated.java
@@ -432,6 +432,11 @@ public class IrBlackBoxInlineCodegenTestGenerated extends AbstractIrBlackBoxInli
                 KotlinTestUtils.assertAllTestsPresentByMetadata(this.getClass(), new File("compiler/testData/codegen/boxInline/anonymousObject/sam"), Pattern.compile("^(.+)\\.kt$"), TargetBackend.JVM_IR, true);
             }
 
+            @TestMetadata("anonymousObjectToSam.kt")
+            public void testAnonymousObjectToSam() throws Exception {
+                runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt");
+            }
+
             @TestMetadata("kt17091.kt")
             public void testKt17091() throws Exception {
                 runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/kt17091.kt");
diff --git a/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrCompileKotlinAgainstInlineKotlinTestGenerated.java b/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrCompileKotlinAgainstInlineKotlinTestGenerated.java
index 6a215d2143c..c355e776ee2 100644
--- a/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrCompileKotlinAgainstInlineKotlinTestGenerated.java
+++ b/compiler/tests/org/jetbrains/kotlin/codegen/ir/IrCompileKotlinAgainstInlineKotlinTestGenerated.java
@@ -432,6 +432,11 @@ public class IrCompileKotlinAgainstInlineKotlinTestGenerated extends AbstractIrC
                 KotlinTestUtils.assertAllTestsPresentByMetadata(this.getClass(), new File("compiler/testData/codegen/boxInline/anonymousObject/sam"), Pattern.compile("^(.+)\\.kt$"), TargetBackend.JVM_IR, true);
             }
 
+            @TestMetadata("anonymousObjectToSam.kt")
+            public void testAnonymousObjectToSam() throws Exception {
+                runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/anonymousObjectToSam.kt");
+            }
+
             @TestMetadata("kt17091.kt")
             public void testKt17091() throws Exception {
                 runTest("compiler/testData/codegen/boxInline/anonymousObject/sam/kt17091.kt");