diff --git a/compiler/testData/codegen/box/assert/alwaysEnable.kt b/compiler/testData/codegen/box/assert/alwaysEnable.kt
index bbb81fbab3c..098d4d643e6 100644
--- a/compiler/testData/codegen/box/assert/alwaysEnable.kt
+++ b/compiler/testData/codegen/box/assert/alwaysEnable.kt
@@ -2,6 +2,7 @@
 // IGNORE_BACKEND: JS_IR
 // IGNORE_BACKEND: JS_IR_ES6
 // IGNORE_BACKEND: JS
+// IGNORE_NATIVE: optimizationMode=OPT
 // ASSERTIONS_MODE: always-enable
 // WITH_STDLIB
 
diff --git a/compiler/testData/codegen/box/fileCheck/redundant_safepoints.kt b/compiler/testData/codegen/box/fileCheck/redundant_safepoints.kt
index ad1bc5c3373..6245ba43843 100644
--- a/compiler/testData/codegen/box/fileCheck/redundant_safepoints.kt
+++ b/compiler/testData/codegen/box/fileCheck/redundant_safepoints.kt
@@ -1,9 +1,6 @@
 // TARGET_BACKEND: NATIVE
 // FILECHECK_STAGE: RemoveRedundantSafepoints
 
-// KT-64844
-// IGNORE_NATIVE: target=linux_x64 && optimizationMode=OPT
-
 // This test checks:
 // - there is only one safepoint per function
 // - safepoint function is inlined in OPT mode, unless SMALLBINARY is needed (for ex, watchos_arm32)
diff --git a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/compilation/TestCompilation.kt b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/compilation/TestCompilation.kt
index 4b30efd0cb7..ba2159dbaf0 100644
--- a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/compilation/TestCompilation.kt
+++ b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/compilation/TestCompilation.kt
@@ -55,8 +55,8 @@ internal abstract class BasicCompilation<A : TestCompilationArtifact>(
     private fun ArgsBuilder.applyCommonArgs() {
         add("-target", targets.testTarget.name)
         optimizationMode.compilerFlag?.let { compilerFlag -> add(compilerFlag) }
+        if (optimizationMode != OptimizationMode.OPT) add("-enable-assertions")
         add(
-            "-enable-assertions",
             "-Xverify-ir=error"
         )
         addFlattened(binaryOptions.entries) { (name, value) -> listOf("-Xbinary=$name=$value") }
@@ -141,7 +141,7 @@ internal abstract class SourceBasedCompilation<A : TestCompilationArtifact>(
     targets: KotlinNativeTargets,
     home: KotlinNativeHome,
     classLoader: KotlinNativeClassLoader,
-    optimizationMode: OptimizationMode,
+    protected val optimizationMode: OptimizationMode,
     compilerOutputInterceptor: CompilerOutputInterceptor,
     private val threadStateChecker: ThreadStateChecker,
     private val sanitizer: Sanitizer,
@@ -218,7 +218,7 @@ internal class LibraryCompilation(
     dependencies = CategorizedDependencies(dependencies),
     expectedArtifact = expectedArtifact
 ) {
-    override val binaryOptions get() = BinaryOptions.RuntimeAssertionsMode.defaultForTesting
+    override val binaryOptions get() = BinaryOptions.RuntimeAssertionsMode.defaultForTesting(optimizationMode)
 
     override fun applySpecificArgs(argsBuilder: ArgsBuilder) = with(argsBuilder) {
         add(
@@ -253,7 +253,7 @@ internal class ObjCFrameworkCompilation(
     dependencies = CategorizedDependencies(dependencies),
     expectedArtifact = expectedArtifact
 ) {
-    override val binaryOptions get() = BinaryOptions.RuntimeAssertionsMode.defaultForTesting
+    override val binaryOptions get() = BinaryOptions.RuntimeAssertionsMode.defaultForTesting(optimizationMode)
 
     override fun applySpecificArgs(argsBuilder: ArgsBuilder) = with(argsBuilder) {
         add(
@@ -356,7 +356,7 @@ internal class ExecutableCompilation(
     expectedArtifact = expectedArtifact
 ) {
     private val cacheMode: CacheMode = settings.get()
-    override val binaryOptions = BinaryOptions.RuntimeAssertionsMode.chooseFor(cacheMode)
+    override val binaryOptions = BinaryOptions.RuntimeAssertionsMode.chooseFor(cacheMode, optimizationMode)
 
     private val partialLinkageConfig: UsedPartialLinkageConfig = settings.get()
 
@@ -552,10 +552,15 @@ internal class CategorizedDependencies(uncategorizedDependencies: Iterable<TestC
 private object BinaryOptions {
     object RuntimeAssertionsMode {
         // Here the 'default' is in the sense the default for testing, not the default for the compiler.
-        val defaultForTesting: Map<String, String> = mapOf("runtimeAssertionsMode" to "panic")
+        fun defaultForTesting(optimizationMode: OptimizationMode): Map<String, String> = when (optimizationMode) {
+            OptimizationMode.OPT -> mapOf()
+            else -> mapOf("runtimeAssertionsMode" to "panic")
+        }
+
         val forUseWithCache: Map<String, String> = mapOf("runtimeAssertionsMode" to "ignore")
 
-        fun chooseFor(cacheMode: CacheMode) = if (cacheMode.useStaticCacheForDistributionLibraries) forUseWithCache else defaultForTesting
+        fun chooseFor(cacheMode: CacheMode, optimizationMode: OptimizationMode) =
+            if (cacheMode.useStaticCacheForDistributionLibraries) forUseWithCache else defaultForTesting(optimizationMode)
     }
 }