diff --git a/kotlin-native/build-tools/src/main/kotlin/org/jetbrains/kotlin/ExecClang.kt b/kotlin-native/build-tools/src/main/kotlin/org/jetbrains/kotlin/ExecClang.kt
index efcc134f3d9..cd7b92832c8 100644
--- a/kotlin-native/build-tools/src/main/kotlin/org/jetbrains/kotlin/ExecClang.kt
+++ b/kotlin-native/build-tools/src/main/kotlin/org/jetbrains/kotlin/ExecClang.kt
@@ -79,12 +79,39 @@ abstract class ExecClang @Inject constructor(
     // The target can be specified as KonanTarget or as a
     // (nullable, which means host) target name.
 
+    // FIXME: See KT-65542 for details
+    private fun fixBrokenMacroExpansionInXcode15_3(target: String?) = fixBrokenMacroExpansionInXcode15_3(platformManager.targetManager(target).target)
+
+    private fun fixBrokenMacroExpansionInXcode15_3(target: KonanTarget): List<String> {
+        return when (target) {
+            KonanTarget.MACOS_ARM64, KonanTarget.MACOS_X64 -> hashMapOf(
+                "TARGET_OS_OSX" to "1",
+            )
+            KonanTarget.IOS_ARM64 -> hashMapOf(
+                "TARGET_OS_EMBEDDED" to "1",
+                "TARGET_OS_IPHONE" to "1",
+                "TARGET_OS_IOS" to "1",
+            )
+            KonanTarget.TVOS_ARM64 -> hashMapOf(
+                "TARGET_OS_EMBEDDED" to "1",
+                "TARGET_OS_IPHONE" to "1",
+                "TARGET_OS_TV" to "1",
+            )
+            KonanTarget.WATCHOS_ARM64, KonanTarget.WATCHOS_ARM32, KonanTarget.WATCHOS_DEVICE_ARM64 -> hashMapOf(
+                "TARGET_OS_EMBEDDED" to "1",
+                "TARGET_OS_IPHONE" to "1",
+                "TARGET_OS_WATCH" to "1",
+            )
+            else -> emptyMap()
+        }.map { "-D${it.key}=${it.value}" }
+    }
+
     fun execKonanClang(target: String?, action: Action<in ExecSpec>): ExecResult {
-        return this.execClang(clangArgsForCppRuntime(target), action)
+        return this.execClang(clangArgsForCppRuntime(target) + fixBrokenMacroExpansionInXcode15_3(target), action)
     }
 
     fun execKonanClang(target: KonanTarget, action: Action<in ExecSpec>): ExecResult {
-        return this.execClang(clangArgsForCppRuntime(target), action)
+        return this.execClang(clangArgsForCppRuntime(target) + fixBrokenMacroExpansionInXcode15_3(target), action)
     }
 
     /**