diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_CPointer.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_CPointer.kt
index 26cc50c2ba8..c632e0aa286 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_CPointer.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_CPointer.kt
@@ -8,11 +8,9 @@ import kotlinx.cinterop.*
 // CHECK-WINDOWSX64-OPT-LABEL: define zeroext i1 @"kfun:kotlinx.cinterop.CPointer#equals(kotlin.Any?){}kotlin.Boolean"(i8* %0, %struct.ObjHeader* %1)
 // CHECK-OPT: call i8* @"kfun:kotlinx.cinterop#<CPointer-unbox>(kotlin.Any?){}kotlinx.cinterop.CPointer<-1:0>?"
 
+// This test is useless in debug mode.
+// TODO(KT-59288): add ability to ignore tests in debug mode
 // CHECK-DEBUG-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
-// CHECK-DEBUG: [[var1:%[0-9]+]] = invoke i8* @"kfun:kotlinx.cinterop#<get-ptr>
-// CHECK-DEBUG: [[var2:%[0-9]+]] = invoke i8* @"kfun:kotlinx.cinterop#<get-ptr>
-// CHECK-DEBUG: = icmp eq i8* [[var1]], [[var2]]
-// CHECK-DEBUG-LABEL: epilogue:
 
 @kotlinx.cinterop.ExperimentalForeignApi
 fun box(): String = memScoped {
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NativePointed.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NativePointed.kt
index 72ecf2b59cf..2748cdb6420 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NativePointed.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NativePointed.kt
@@ -6,11 +6,9 @@ import kotlinx.cinterop.*
 // CHECK-OPT-LABEL: define i8* @"kfun:kotlinx.cinterop#interpretOpaquePointed(kotlin.native.internal.NativePtr){}kotlinx.cinterop.NativePointed"(i8* %0)
 // CHECK-OPT: call i8* @"kfun:kotlinx.cinterop#<NativePointed-unbox>(kotlin.Any?){}kotlinx.cinterop.NativePointed?"
 
+// This test is useless in debug mode.
+// TODO(KT-59288): add ability to ignore tests in debug mode
 // CHECK-DEBUG-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
-// CHECK-AAPCS-DEBUG: call i1 @IsSubtype(%struct.TypeInfo* %{{[0-9]+}}, %struct.TypeInfo* getelementptr inbounds ({{.*}}@"kclass:kotlinx.cinterop.NativePointed", i32 0, i32 0))
-// CHECK-DEFAULTABI-DEBUG: call zeroext i1 @IsSubtype(%struct.TypeInfo* %{{[0-9]+}}, %struct.TypeInfo* @"kclass:kotlinx.cinterop.NativePointed")
-// CHECK-WINDOWSX64-DEBUG: call zeroext i1 @IsSubtype(%struct.TypeInfo* %{{[0-9]+}}, %struct.TypeInfo* getelementptr inbounds ({{.*}}@"kclass:kotlinx.cinterop.NativePointed", i32 0, i32 0))
-// CHECK-DEBUG-LABEL: epilogue:
 
 @kotlinx.cinterop.ExperimentalForeignApi
 fun box(): String = memScoped {
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NonNullNativePtr.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NonNullNativePtr.kt
index 0acdc20151d..b1151aba676 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NonNullNativePtr.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_NonNullNativePtr.kt
@@ -8,11 +8,9 @@ import kotlinx.cinterop.*
 // CHECK-WINDOWSX64-OPT-LABEL: define zeroext i1 @"kfun:kotlin.native.internal.NonNullNativePtr#equals(kotlin.Any?){}kotlin.Boolean"(i8* %0, %struct.ObjHeader* %1)
 // CHECK-OPT: call i8* @"kfun:kotlin.native.internal#<NonNullNativePtr-unbox>(kotlin.Any?){}kotlin.native.internal.NonNullNativePtr?"
 
+// This test is useless in debug mode.
+// TODO(KT-59288): add ability to ignore tests in debug mode
 // CHECK-DEBUG-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
-// CHECK-AAPCS-DEBUG: invoke i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-DEFAULTABI-DEBUG: invoke zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-WINDOWSX64-DEBUG: invoke zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-DEBUG-LABEL: epilogue:
 
 @kotlinx.cinterop.ExperimentalForeignApi
 fun box(): String = memScoped {
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_StableRef.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_StableRef.kt
index e13abba8ca6..3648db37890 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_StableRef.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_StableRef.kt
@@ -11,14 +11,10 @@ import kotlinx.cinterop.*
 
 // CHECK-OPT-LABEL: epilogue:
 
-
+// This test is useless in debug mode.
+// TODO(KT-59288): add ability to ignore tests in debug mode
 // CHECK-DEBUG-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
 
-// CHECK-DEBUG: [[result:%[0-9]+]] = icmp eq i8*
-// CHECK-DEBUG: store i1 [[result]], i1* %isEqual
-
-// CHECK-DEBUG-LABEL: epilogue:
-
 @kotlinx.cinterop.ExperimentalForeignApi
 fun box(): String {
     val ref1 = StableRef.create(Any())
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UByteArray.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UByteArray.kt
index 6462cc5327d..da42ac9e61c 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UByteArray.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UByteArray.kt
@@ -8,9 +8,6 @@
 // CHECK-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
 
 // CHECK-OPT: call %struct.ObjHeader* @"kfun:kotlin#<UByteArray-unbox>(kotlin.Any?){}kotlin.UByteArray?"
-// CHECK-AAPCS-DEBUG: call i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-DEFAULTABI-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-WINDOWSX64-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
 
 // CHECK-LABEL: epilogue:
 
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UIntArray.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UIntArray.kt
index 4ee27064953..860590d560a 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UIntArray.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UIntArray.kt
@@ -8,9 +8,6 @@
 // CHECK-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
 
 // CHECK-OPT: call %struct.ObjHeader* @"kfun:kotlin#<UIntArray-unbox>(kotlin.Any?){}kotlin.UIntArray?"
-// CHECK-AAPCS-DEBUG: call i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-DEFAULTABI-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-WINDOWSX64-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
 
 // CHECK-LABEL: epilogue:
 
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_ULongArray.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_ULongArray.kt
index 9e878798f35..d3272dbb25c 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_ULongArray.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_ULongArray.kt
@@ -8,9 +8,6 @@
 // CHECK-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
 
 // CHECK-OPT: call %struct.ObjHeader* @"kfun:kotlin#<ULongArray-unbox>(kotlin.Any?){}kotlin.ULongArray?"
-// CHECK-AAPCS-DEBUG: call i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-DEFAULTABI-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-WINDOWSX64-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
 
 // CHECK-LABEL: epilogue:
 
diff --git a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UShortArray.kt b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UShortArray.kt
index 888ab68739a..818fc7745f4 100644
--- a/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UShortArray.kt
+++ b/compiler/testData/codegen/box/fileCheck/kt53261/kt53261_noinline_UShortArray.kt
@@ -8,9 +8,6 @@
 // CHECK-LABEL: define %struct.ObjHeader* @"kfun:#box(){}kotlin.String"
 
 // CHECK-OPT: call %struct.ObjHeader* @"kfun:kotlin#<UShortArray-unbox>(kotlin.Any?){}kotlin.UShortArray?"
-// CHECK-AAPCS-DEBUG: call i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-DEFAULTABI-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
-// CHECK-WINDOWSX64-DEBUG: call zeroext i1 @"kfun:kotlin.Any#equals(kotlin.Any?){}kotlin.Boolean-trampoline"
 
 // CHECK-LABEL: epilogue: