diff --git a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/NativeTestSupport.kt b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/NativeTestSupport.kt
index 7f9aafcc934..eb200d073bc 100644
--- a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/NativeTestSupport.kt
+++ b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/NativeTestSupport.kt
@@ -269,7 +269,8 @@ internal object NativeTestSupport {
         val cacheMode = ClassLevelProperty.CACHE_MODE.readValue(
             enforcedProperties,
             CacheMode.Alias.values(),
-            default = defaultCache
+            default = if (optimizationMode != OptimizationMode.OPT) defaultCache
+                      else CacheMode.Alias.NO,
         )
         val useStaticCacheForUserLibraries = when (cacheMode) {
             CacheMode.Alias.NO -> return CacheMode.WithoutCache
diff --git a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/settings/TestProcessSettings.kt b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/settings/TestProcessSettings.kt
index 2a3820b79f3..fa1eb824834 100644
--- a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/settings/TestProcessSettings.kt
+++ b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/support/settings/TestProcessSettings.kt
@@ -9,10 +9,12 @@ import org.jetbrains.kotlin.config.LanguageVersion
 import org.jetbrains.kotlin.konan.properties.resolvablePropertyList
 import org.jetbrains.kotlin.konan.target.Distribution
 import org.jetbrains.kotlin.konan.target.KonanTarget
+import org.jetbrains.kotlin.konan.test.blackbox.support.ClassLevelProperty
 import org.jetbrains.kotlin.konan.test.blackbox.support.MutedOption
 import org.jetbrains.kotlin.konan.test.blackbox.support.runner.RunnerWithExecutor
 import org.jetbrains.kotlin.konan.test.blackbox.support.runner.NoopTestRunner
 import org.jetbrains.kotlin.konan.test.blackbox.support.runner.Runner
+import org.jetbrains.kotlin.test.services.JUnit5Assertions.assertFalse
 import org.jetbrains.kotlin.test.services.JUnit5Assertions.assertTrue
 import java.io.File
 import java.io.IOException
@@ -227,6 +229,13 @@ internal sealed class CacheMode {
         override val makePerFileCaches: Boolean,
         override val alias: Alias,
     ) : CacheMode() {
+        init {
+            assertFalse (optimizationMode == OptimizationMode.OPT) {
+                "Static caches are incompatible with `-P${ClassLevelProperty.OPTIMIZATION_MODE.propertyName}=${OptimizationMode.OPT.name}`.\n" +
+                "To test in ${OptimizationMode.OPT.name} mode, either don't specify `-P${ClassLevelProperty.CACHE_MODE.propertyName}`, or set it to ${Alias.NO.name}."
+            }
+        }
+
         override val staticCacheForDistributionLibrariesRootDir: File = File(distribution.klib)
             .resolve("cache")
             .resolve(