diff --git a/kotlin-native/runtime/src/main/cpp/Runtime.cpp b/kotlin-native/runtime/src/main/cpp/Runtime.cpp
index 365fac3d966..06d74079389 100644
--- a/kotlin-native/runtime/src/main/cpp/Runtime.cpp
+++ b/kotlin-native/runtime/src/main/cpp/Runtime.cpp
@@ -24,8 +24,14 @@
 #include "ObjCExportInit.h"
 #include "Porting.h"
 #include "Runtime.h"
+#include "RuntimePrivate.hpp"
 #include "Worker.h"
 
+using kotlin::internal::FILE_NOT_INITIALIZED;
+using kotlin::internal::FILE_BEING_INITIALIZED;
+using kotlin::internal::FILE_INITIALIZED;
+using kotlin::internal::FILE_FAILED_TO_INITIALIZE;
+
 typedef void (*Initializer)(int initialize, MemoryState* memory);
 struct InitNode {
   Initializer init;
@@ -410,11 +416,6 @@ RUNTIME_NOTHROW void Kotlin_initRuntimeIfNeededFromKotlin() {
     }
 }
 
-static constexpr int FILE_NOT_INITIALIZED = 0;
-static constexpr int FILE_BEING_INITIALIZED = 1;
-static constexpr int FILE_INITIALIZED = 2;
-static constexpr int FILE_FAILED_TO_INITIALIZE = 3;
-
 void CallInitGlobalPossiblyLock(int volatile* state, void (*init)()) {
     int localState = *state;
     if (localState == FILE_INITIALIZED) return;
@@ -423,10 +424,13 @@ void CallInitGlobalPossiblyLock(int volatile* state, void (*init)()) {
     int threadId = konan::currentThreadId();
     if ((localState & 3) == FILE_BEING_INITIALIZED) {
         if ((localState & ~3) != (threadId << 2)) {
+            // Switch to the native state to avoid dead-locks.
+            kotlin::ThreadStateGuard guard(kotlin::ThreadState::kNative);
             do {
                 localState = *state;
                 if (localState == FILE_FAILED_TO_INITIALIZE)
-                    ThrowFileFailedToInitializeException();
+                    // Call of a Kotlin function.
+                    kotlin::CallWithThreadState<kotlin::ThreadState::kRunnable>(ThrowFileFailedToInitializeException);
             } while (localState != FILE_INITIALIZED);
         }
         return;
@@ -445,10 +449,13 @@ void CallInitGlobalPossiblyLock(int volatile* state, void (*init)()) {
 #endif
         *state = FILE_INITIALIZED;
     } else {
+        // Switch to the native state to avoid dead-locks.
+        kotlin::ThreadStateGuard guard(kotlin::ThreadState::kNative);
         do {
             localState = *state;
             if (localState == FILE_FAILED_TO_INITIALIZE)
-                ThrowFileFailedToInitializeException();
+                // Call of a Kotlin function.
+                kotlin::CallWithThreadState<kotlin::ThreadState::kRunnable>(ThrowFileFailedToInitializeException);
         } while (localState != FILE_INITIALIZED);
     }
 }
diff --git a/kotlin-native/runtime/src/main/cpp/RuntimePrivate.hpp b/kotlin-native/runtime/src/main/cpp/RuntimePrivate.hpp
new file mode 100644
index 00000000000..f86dcdd307e
--- /dev/null
+++ b/kotlin-native/runtime/src/main/cpp/RuntimePrivate.hpp
@@ -0,0 +1,17 @@
+/*
+ * Copyright 2010-2021 JetBrains s.r.o. Use of this source code is governed by the Apache 2.0 license
+ * that can be found in the LICENSE file.
+ */
+
+#pragma once
+
+namespace kotlin {
+namespace internal {
+
+inline constexpr int FILE_NOT_INITIALIZED = 0;
+inline constexpr int FILE_BEING_INITIALIZED = 1;
+inline constexpr int FILE_INITIALIZED = 2;
+inline constexpr int FILE_FAILED_TO_INITIALIZE = 3;
+
+} // namespace internal
+} // namespace kotlin
diff --git a/kotlin-native/runtime/src/mm/cpp/ThreadSuspensionTest.cpp b/kotlin-native/runtime/src/mm/cpp/ThreadSuspensionTest.cpp
index a0ffc5530b2..d9c836d6e21 100644
--- a/kotlin-native/runtime/src/mm/cpp/ThreadSuspensionTest.cpp
+++ b/kotlin-native/runtime/src/mm/cpp/ThreadSuspensionTest.cpp
@@ -4,14 +4,18 @@
  */
 
 #include "MemoryPrivate.hpp"
+#include "Runtime.h"
+#include "RuntimePrivate.hpp"
 #include "ThreadSuspension.hpp"
 #include "ThreadState.hpp"
 
 #include <gtest/gtest.h>
 #include <gmock/gmock.h>
 
+#include <future>
 #include <thread>
 #include <TestSupport.hpp>
+#include <TestSupportCompilerGenerated.hpp>
 
 #include <iostream>
 
@@ -55,6 +59,17 @@ void reportProgress(size_t currentIteration, size_t totalIterations) {
     }
 }
 
+testing::MockFunction<void()>* initializationMock = nullptr;
+
+void initializationFunction() {
+    ASSERT_NE(initializationMock, nullptr);
+    initializationMock->Call();
+}
+
+test_support::ScopedMockFunction<void(), /* Strict = */ true> ScopedInitializationMock() {
+    return test_support::ScopedMockFunction(&initializationMock);
+}
+
 } // namespace
 
 class ThreadSuspensionTest : public ::testing::Test {
@@ -203,3 +218,56 @@ TEST_F(ThreadSuspensionTest, ConcurrentSuspend) {
     }
     EXPECT_EQ(successCount, 1u);
 }
+
+TEST_F(ThreadSuspensionTest, FileInitializationWithSuspend) {
+    ASSERT_THAT(collectThreadData(), testing::IsEmpty());
+    ASSERT_FALSE(mm::IsThreadSuspensionRequested());
+
+    volatile int lock = internal::FILE_NOT_INITIALIZED;
+
+    auto scopedInitializationMock = ScopedInitializationMock();
+    EXPECT_CALL(*scopedInitializationMock, Call()).WillOnce([] {
+        EXPECT_EQ(GetThreadState(), ThreadState::kRunnable);
+        // Give other threads a chance to call CallInitGlobalPossiblyLock.
+        std::this_thread::yield();
+        mm::SuspendIfRequested();
+    });
+
+    for (size_t i = 0; i < kThreadCount; i++) {
+        threads.emplace_back([this, i, &lock] {
+            ScopedMemoryInit init;
+            auto* threadData = init.memoryState()->GetThreadData();
+            ASSERT_EQ(threadData->state(), ThreadState::kRunnable);
+
+            waitUntilCanStart(i);
+
+            CallInitGlobalPossiblyLock(&lock, initializationFunction);
+            // Try to suspend to handle a case when this thread doesn't call the initialization function.
+            mm::SuspendIfRequested();
+        });
+    }
+    waitUntilThreadsAreReady();
+
+    auto gcThread = std::async(std::launch::async, [] {
+        mm::RequestThreadsSuspension();
+        mm::WaitForThreadsSuspension();
+        mm::ResumeThreads();
+    });
+    while(!mm::IsThreadSuspensionRequested()) {
+    }
+    canStart = true;
+
+    auto futureStatus = gcThread.wait_for(std::chrono::seconds(10));
+    EXPECT_NE(futureStatus, std::future_status::timeout);
+    if (futureStatus == std::future_status::timeout) {
+        // Possibly CallInitGlobalPossiblyLock is hanging in a dead-lock.
+        // Set the lock variable to FILE_INITIALIZED to interrupt the loop inside CallInitGlobalPossiblyLock.
+        // And wait for the gc thread to stop.
+        lock = internal::FILE_INITIALIZED;
+        gcThread.wait();
+    }
+
+    for (auto& t : threads) {
+        t.join();
+    }
+}
\ No newline at end of file
diff --git a/kotlin-native/runtime/tsan_suppressions.txt b/kotlin-native/runtime/tsan_suppressions.txt
index 7805285b034..ee58e333fc1 100644
--- a/kotlin-native/runtime/tsan_suppressions.txt
+++ b/kotlin-native/runtime/tsan_suppressions.txt
@@ -1,3 +1,7 @@
 # Trust mimalloc to be thread safe.
 race:^mi_
 race:^_mi_
+
+# Spin lock on a volatile int in initialization of globals
+# TODO: Remove when volatile int is replaced with a C++ atomic.
+race:CallInitGlobalPossiblyLock
\ No newline at end of file