diff --git a/compiler/ir/backend.common/src/org/jetbrains/kotlin/backend/common/lower/DefaultArgumentStubGenerator.kt b/compiler/ir/backend.common/src/org/jetbrains/kotlin/backend/common/lower/DefaultArgumentStubGenerator.kt
index f0cc6287f14..0d30338a23c 100644
--- a/compiler/ir/backend.common/src/org/jetbrains/kotlin/backend/common/lower/DefaultArgumentStubGenerator.kt
+++ b/compiler/ir/backend.common/src/org/jetbrains/kotlin/backend/common/lower/DefaultArgumentStubGenerator.kt
@@ -391,6 +391,7 @@ class DefaultParameterCleaner constructor(val context: CommonBackendContext) : F
 // TODO this implementation is exponential
 private fun IrFunction.needsDefaultArgumentsLowering(skipInlineMethods: Boolean): Boolean {
     if (isInline && skipInlineMethods) return false
+    if (isEffectivelyExternal()) return false
     if (valueParameters.any { it.defaultValue != null }) return true
 
     if (this !is IrSimpleFunction) return false
diff --git a/compiler/ir/backend.js/src/org/jetbrains/kotlin/ir/backend/js/transformers/irToJs/IrElementToJsExpressionTransformer.kt b/compiler/ir/backend.js/src/org/jetbrains/kotlin/ir/backend/js/transformers/irToJs/IrElementToJsExpressionTransformer.kt
index a5410bdccac..a8f9b92d555 100644
--- a/compiler/ir/backend.js/src/org/jetbrains/kotlin/ir/backend/js/transformers/irToJs/IrElementToJsExpressionTransformer.kt
+++ b/compiler/ir/backend.js/src/org/jetbrains/kotlin/ir/backend/js/transformers/irToJs/IrElementToJsExpressionTransformer.kt
@@ -162,9 +162,17 @@ class IrElementToJsExpressionTransformer : BaseIrElementToJsNodeTransformer<JsEx
             val targetName = context.getNameForSymbol(target.symbol)
             val qPrototype = JsNameRef(targetName, prototypeOf(qualifierName))
             val callRef = JsNameRef(Namer.CALL_FUNCTION, qPrototype)
-            return JsInvocation(callRef, jsDispatchReceiver?.let { listOf(it) + arguments } ?: arguments)
+            return JsInvocation(callRef, jsDispatchReceiver?.let { receiver -> listOf(receiver) + arguments } ?: arguments)
         }
 
+        val varargParameterIndex = function.valueParameters.indexOfFirst { it.varargElementType != null }
+        val isExternalVararg = function.isEffectivelyExternal() && varargParameterIndex != -1
+
+        val symbolName = context.getNameForSymbol(symbol)
+        val ref = if (function is IrSimpleFunction && jsDispatchReceiver != null) JsNameRef(symbolName, jsDispatchReceiver) else JsNameRef(
+            symbolName
+        )
+
         return if (function is IrConstructor) {
             // Inline class primary constructor takes a single value of to
             // initialize underlying property.
@@ -177,12 +185,66 @@ class IrElementToJsExpressionTransformer : BaseIrElementToJsNodeTransformer<JsEx
                 // Argument value constructs unboxed inline class instance
                 arguments.single()
             } else {
-                JsNew(context.getNameForSymbol(symbol).makeRef(), arguments)
+                JsNew(ref, arguments)
+            }
+        } else if (isExternalVararg) {
+
+            // External vararg arguments should be represented in JS as multiple "plain" arguments (opposed to arrays in Kotlin)
+            // We are using `Function.prototype.apply` function to pass all arguments as a single array.
+            // For this purpose are concatenating non-vararg arguments with vararg.
+            // TODO: Don't use `Function.prototype.apply` when number of arguments is known at compile time (e.g. there are no spread operators)
+            val arrayConcat = JsNameRef("concat", JsArrayLiteral())
+            val arraySliceCall = JsNameRef("call", JsNameRef("slice", JsArrayLiteral()))
+
+            val argumentsAsSingleArray = JsInvocation(
+                arrayConcat,
+                listOfNotNull(jsExtensionReceiver) + arguments.mapIndexed { index, argument ->
+                    when (index) {
+
+                        // Call `Array.prototype.slice` on vararg arguments in order to convert array-like objects into proper arrays
+                        // TODO: Optimize for proper arrays
+                        varargParameterIndex -> JsInvocation(arraySliceCall, argument)
+
+                        // TODO: Don't wrap non-array-like arguments with array literal
+                        // TODO: Wrap adjacent non-vararg arguments in a single array literal
+                        else -> JsArrayLiteral(listOf(argument))
+                    }
+                }
+            )
+
+            if (function is IrSimpleFunction && jsDispatchReceiver != null) {
+                // TODO: Do not create IIFE when receiver expression is simple or has no side effects
+                // TODO: Do not create IIFE at all? (Currently there is no reliable way to create temporary variable in current scope)
+                val receiverName = context.currentScope.declareFreshName("\$externalVarargReceiverTmp")
+                val receiverRef = receiverName.makeRef()
+                JsInvocation(
+                    // Create scope for temporary variable holding dispatch receiver
+                    // It is used both during method reference and passing `this` value to `apply` function.
+                    JsFunction(
+                        context.currentScope,
+                        JsBlock(
+                            JsVars(JsVars.JsVar(receiverName, jsDispatchReceiver)),
+                            JsReturn(
+                                JsInvocation(
+                                    JsNameRef("apply", JsNameRef(symbolName, receiverRef)),
+                                    listOf(
+                                        receiverRef,
+                                        argumentsAsSingleArray
+                                    )
+                                )
+                            )
+                        ),
+                        "VarargIIFE"
+                    )
+                )
+            } else {
+                JsInvocation(
+                    JsNameRef("apply", JsNameRef(symbolName)),
+                    listOf(JsNullLiteral(), argumentsAsSingleArray)
+                )
             }
         } else {
-            val symbolName = context.getNameForSymbol(symbol)
-            val ref = if (jsDispatchReceiver != null) JsNameRef(symbolName, jsDispatchReceiver) else JsNameRef(symbolName)
-            JsInvocation(ref, jsExtensionReceiver?.let { listOf(jsExtensionReceiver) + arguments } ?: arguments)
+            JsInvocation(ref, listOfNotNull(jsExtensionReceiver) + arguments)
         }
     }
 
diff --git a/js/js.translator/testData/box/jsModule/topLevelVarargFun.kt b/js/js.translator/testData/box/jsModule/topLevelVarargFun.kt
index c830c4800fd..ef9f66f25d1 100644
--- a/js/js.translator/testData/box/jsModule/topLevelVarargFun.kt
+++ b/js/js.translator/testData/box/jsModule/topLevelVarargFun.kt
@@ -1,4 +1,3 @@
-// IGNORE_BACKEND: JS_IR
 // EXPECTED_REACHABLE_NODES: 1283
 // MODULE_KIND: AMD
 @JsModule("bar")
diff --git a/js/js.translator/testData/box/native/objectFunWithVararg.kt b/js/js.translator/testData/box/native/objectFunWithVararg.kt
index f7dec09bffd..94433915ba8 100644
--- a/js/js.translator/testData/box/native/objectFunWithVararg.kt
+++ b/js/js.translator/testData/box/native/objectFunWithVararg.kt
@@ -1,4 +1,3 @@
-// IGNORE_BACKEND: JS_IR
 // EXPECTED_REACHABLE_NODES: 1281
 import Test.test
 
diff --git a/js/js.translator/testData/box/native/vararg.kt b/js/js.translator/testData/box/native/vararg.kt
index 2d6ca57542b..17e268149fc 100644
--- a/js/js.translator/testData/box/native/vararg.kt
+++ b/js/js.translator/testData/box/native/vararg.kt
@@ -1,4 +1,3 @@
-// IGNORE_BACKEND: JS_IR
 // EXPECTED_REACHABLE_NODES: 1314
 package foo